abstract：:The ubiquitin E3 ligase DELTEX1 (DTX1) is specifically downregulated in gastric cancer tissues, and expression of DTX1 is linked to better prognoses and survival in gastric cancer. Cellular FLICE inhibitory protein (c-FLIP) is known for its pivotal role in the resistance of cancer cells to death receptor-induced cell ...

journal_title：Cell death & disease

authors： Hsu TS,Mo ST,Hsu PN,Lai MZ

更新日期：2018-01-26 00:00:00

abstract：:Cancer cells including glioblastoma have typically evolved multiple mechanisms to escape programmed cell death in order to maintain their survival. Defects in cell death mechanisms not only facilitate tumorigenesis but also ensure resistance to current anticancer therapies. This emphasizes that targeting cell death pa...

journal_title：Cell death & disease

authors： Fulda S

更新日期：2018-01-25 00:00:00

abstract：:The incidence of malignant melanoma has continued to rise during the past decades. However, in the last few years, treatment protocols have significantly been improved thanks to a better understanding of the key oncogenes and signaling pathways involved in its pathogenesis and progression. Anticancer therapy would eit...

journal_title：Cell death & disease

authors： Mattia G,Puglisi R,Ascione B,Malorni W,Carè A,Matarrese P

更新日期：2018-01-25 00:00:00

abstract：:The identification of specific drug targets guides the development of precise cancer treatments. Compared with oncogenes, tumor suppressor genes have been poorly studied in the treatment of breast cancer. We integrate the microRNA expression array from GEO (Gene Expression Omnibus) and TCGA (The Cancer Genome Atlas) d...

journal_title：Cell death & disease

authors： Li M,Han Y,Zhou H,Li X,Lin C,Zhang E,Chi X,Hu J,Xu H

更新日期：2018-01-24 00:00:00

abstract：:TAF6δ is a pro-apoptotic splice variant of the RNA polymerase II general transcription factor, TAF6, that can dictate life vs. death decisions in animal cells. TAF6δ stands out from classical pro-apoptotic proteins because it is encoded by a gene that is essential at the cellular level, and because it functions as a c...

journal_title：Cell death & disease

authors： Delannoy A,Wilhelm E,Eilebrecht S,Alvarado-Cuevas EM,Benecke AG,Bell B

更新日期：2018-01-22 00:00:00

abstract：:Melatonin, an endogenous hormone molecule, has a variety of biological functions, but a functional role of melatonin in the infection of Gram-negative bacterium Vibrio vulnificus has yet to be described. In this study, we investigated the molecular mechanism of melatonin in the apoptosis of human intestinal epithelial...

journal_title：Cell death & disease

authors： Lee SJ,Lee HJ,Jung YH,Kim JS,Choi SH,Han HJ

更新日期：2018-01-19 00:00:00

abstract：:Vascularization deficiency caused a lot of diseases, such as diabetes ulcer and myocardial infarction. Mesenchymal stem cells (MSCs), with the self-renewal and multipotent differentiation capacities, have been used for many diseases treatment through regulation microenvironment. Numerous studies reported that MSCs tra...

journal_title：Cell death & disease

authors： An Y,Liu WJ,Xue P,Ma Y,Zhang LQ,Zhu B,Qi M,Li LY,Zhang YJ,Wang QT,Jin Y

更新日期：2018-01-19 00:00:00

abstract：:Acute pancreatitis (AP) is an acute inflammatory process of the pancreas that is characterized by inflammation, edema, vacuolization and necrosis, which has significant morbidity and lethality. The pathogenesis of AP has not been established completely. An early and critical feature of AP is the aberrant signaling of ...

journal_title：Cell death & disease

authors： Zhu ZD,Yu T,Liu HJ,Jin J,He J

更新日期：2018-01-19 00:00:00

abstract：:Monoglyceride lipase (MGL) is a recently discovered cancer-related protein. The role of MGL in tumorigenesis remains to be fully elucidated. We have previously shown that MGL expression was reduced or absent in multiple human malignancies, and overexpression of MGL inhibited cancer cell growth. Here, we have generated...

journal_title：Cell death & disease

authors： Liu R,Wang X,Curtiss C,Landas S,Rong R,Sheikh MS,Huang Y

更新日期：2018-01-18 00:00:00

abstract：:Mesenchymal stem cells (MSCs) have been reported to localize in colorectal carcinomas, and participate in the formation of the tumor microenvironment. They have recently been isolated from colorectal cancer tissues, and are implicated in the growth, invasion, and metastasis of cancer cells. However, the roles and deta...

journal_title：Cell death & disease

authors： Zhang X,Hu F,Li G,Li G,Yang X,Liu L,Zhang R,Zhang B,Feng Y

更新日期：2018-01-18 00:00:00

abstract：:Protein kinase C (PKC) isozymes play major roles in human diseases, including cancer. Yet, the poor understanding of isozymes-specific functions and the limited availability of selective pharmacological modulators of PKC isozymes have limited the clinical translation of PKC-targeting agents. Here, we report the first ...

journal_title：Cell death & disease

authors： Bessa C,Soares J,Raimundo L,Loureiro JB,Gomes C,Reis F,Soares ML,Santos D,Dureja C,Chaudhuri SR,Lopez-Haber C,Kazanietz MG,Gonçalves J,Simões MF,Rijo P,Saraiva L

更新日期：2018-01-18 00:00:00

abstract：:Osteoclasts are absorptive cells that play a critical role in homeostatic bone remodeling and pathological bone resorption. Emerging evidence suggests an important role of epigenetic regulation in osteoclastogenesis. In this study, we investigated the role of DOT1L, which regulates gene expression epigenetically by hi...

journal_title：Cell death & disease

authors： Gao Y,Ge W

更新日期：2018-01-18 00:00:00

abstract：:Inflammasomes are multimeric protein complexes that assemble upon sensing of a variety of stress factors. Their formation results in caspase-1-mediated activation and secretion of the pro-inflammatory cytokines pro-interleukin(IL)-1β and -18, which induce an inflammatory response. Inflammation is supported by a lytic ...

journal_title：Cell death & disease

authors： Sand J,Haertel E,Biedermann T,Contassot E,Reichmann E,French LE,Werner S,Beer HD

更新日期：2018-01-18 00:00:00

abstract：:Esophageal squamous cell carcinoma (ESCC) is one of the deadliest cancers, and it requires novel treatment approaches and effective drugs. In the present study, we found that treatment with plumbagin, a natural compound, reduced proliferation and survival of the KYSE150 and KYSE450 ESCC cell lines in a dose-dependent ...

journal_title：Cell death & disease

authors： Cao YY,Yu J,Liu TT,Yang KX,Yang LY,Chen Q,Shi F,Hao JJ,Cai Y,Wang MR,Lu WH,Zhang Y

更新日期：2018-01-16 00:00:00

abstract：:Hepatocellular carcinoma (HCC) represents the second cause of cancer-related mortality worldwide and is associated with poor prognosis, especially in patients not amenable for curative treatments. The multi-kinase inhibitor sorafenib represents the first-line treatment option for advanced HCC; nevertheless, its effect...

journal_title：Cell death & disease

authors： Pollutri D,Patrizi C,Marinelli S,Giovannini C,Trombetta E,Giannone FA,Baldassarre M,Quarta S,Vandewynckel YP,Vandierendonck A,Van Vlierberghe H,Porretti L,Negrini M,Bolondi L,Gramantieri L,Fornari F

更新日期：2018-01-05 00:00:00

abstract：:Recent reports show that B7-H4 is highly expressed in a variety of tumor cells, functions as a negative regulator of T cells and then promotes tumor progression. However, its expression and role in intrahepatic cholangiocarcinoma (ICC) remain unclear. In present study, B7-H4 expression in ICC and peritumoral tissues w...

journal_title：Cell death & disease

authors： Xie N,Cai JB,Zhang L,Zhang PF,Shen YH,Yang X,Lu JC,Gao DM,Kang Q,Liu LX,Zhang C,Huang XY,Zou H,Zhang XY,Song ZJ,Sun HX,Fu BM,Ke AW,Shi GM

更新日期：2017-12-13 00:00:00

abstract：:Mitogen-activated protein kinases (MAPKs) are conserved protein kinases that regulate a variety of important cellular signaling pathways. Among them, c-Jun N-terminal kinases (JNK) are known to be activated by various environmental stresses including virus infections. Previously, activation of the JNK pathway has been...

journal_title：Cell death & disease

authors： Fung TS,Liu DX

更新日期：2017-12-13 00:00:00

abstract：:Wallerian degeneration is an active program tightly associated with axonal degeneration, required for axonal regeneration and functional recovery after nerve damage. Here we provide a functional molecular foundation for our undertstanding of the complex non-cell autonomous role of glial cells in the regulation of axon...

journal_title：Cell death & disease

authors： Catenaccio A,Llavero Hurtado M,Diaz P,Lamont DJ,Wishart TM,Court FA

更新日期：2017-11-09 00:00:00

abstract：:The voltage-gated K+ channel has key roles in the vasculature and in atrial excitability and contributes to apoptosis in various tissues. In this study, we have explored its regulation by carbon monoxide (CO), a product of the cytoprotective heme oxygenase enzymes, and a recognized toxin. CO inhibited recombinant Kv1....

journal_title：Cell death & disease

authors： Al-Owais MM,Hettiarachchi NT,Boyle JP,Scragg JL,Elies J,Dallas ML,Lippiat JD,Steele DS,Peers C

更新日期：2017-11-02 00:00:00

abstract：:UV irradiation elicits acute inflammation in the skin by increasing proinflammatory cytokine production in keratinocytes. However, the downstream protein target(s) that link UV radiation to the activation of signaling pathways responsible for cytokine expression have not been fully elucidated. In this study, we report...

journal_title：Cell death & disease

authors： Lee SJ,Lee KB,Son YH,Shin J,Lee JH,Kim HJ,Hong AY,Bae HW,Kwon MA,Lee WJ,Kim JH,Lee DH,Jeong EM,Kim IG

更新日期：2017-10-26 00:00:00

abstract：:Soluble Axl (sAxl) was recently shown to be strongly released into the blood during liver fibrogenesis and hepatocellular carcinoma suggesting sAxl as a biomarker of liver diseases. In this study we are the first to evaluate sAxl in human serum in comparison to Enhanced Liver Fibrosis (ELF) test and transient elastogr...

journal_title：Cell death & disease

authors： Staufer K,Dengler M,Huber H,Marculescu R,Stauber R,Lackner C,Dienes HP,Kivaranovic D,Schachner C,Zeitlinger M,Wulkersdorfer B,Rauch P,Prager G,Trauner M,Mikulits W

更新日期：2017-10-26 00:00:00

abstract：:Aneuploidy including trisomy results in developmental disabilities and is the leading cause of miscarriages in humans. Unlike trisomy 21, pathogenic mechanisms of trisomy 18 remain unclear. Here, we successfully generated induced pluripotent stem cells (iPSCs) from human amniotic fluid cells (AFCs) with trisomy 18 pre...

journal_title：Cell death & disease

authors： Li T,Zhao H,Han X,Yao J,Zhang L,Guo Y,Shao Z,Jin Y,Lai D

更新日期：2017-10-26 00:00:00

abstract：:It is long established that tumour-initiating cancer stem cells (CSCs) possess chemoresistant properties. However, little is known of the mechanisms involved, particularly with respect to the organisation of CSCs as stem-progenitor-differentiated cell hierarchies. Here we aimed to elucidate the relationship between CS...

journal_title：Cell death & disease

authors： Ffrench B,Gasch C,Hokamp K,Spillane C,Blackshields G,Mahgoub TM,Bates M,Kehoe L,Mooney A,Doyle R,Doyle B,O'Donnell D,Gleeson N,Hennessy BT,Stordal B,O'Riain C,Lambkin H,O'Toole S,O'Leary JJ,Gallagher MF

更新日期：2017-10-19 00:00:00

abstract：:15-Lipoxygenase-1 (15-LO-1) is involved in many pathological processes. The purpose of this study was to determine the potential role of 15-LO-1 in osteoarthritis (OA). The levels of 15-LO-1 expression were measured by western blotting and quantitative real-time PCR in articular cartilage from the OA rat models and OA...

journal_title：Cell death & disease

authors： Chen K,Yan Y,Li C,Yuan J,Wang F,Huang P,Qian N,Qi J,Zhou H,Zhou Q,Deng L,He C,Guo L

更新日期：2017-10-12 00:00:00

abstract：:Enhanced Myd88 expression has been found in various parenchymal tumors especially in hepatocellular carcinoma with little mechanism of its upregulation known. A lot of long non-coding RNAs are reported to regulate the protein-coding genes which have location association through various mechanisms. In our study we conf...

journal_title：Cell death & disease

authors： Xu X,Yin Y,Tang J,Xie Y,Han Z,Zhang X,Liu Q,Qin X,Huang X,Sun B

更新日期：2017-10-12 00:00:00

abstract：:Due to limited treatment options, pre-eclampsia (PE) is associated with fetal perinatal and maternal morbidity and mortality. During the causes of PE, failure of uterine spiral artery remodeling which might be related to functioning abnormally of trophoblast cells, result in the occurrence and progression of PE. Recen...

journal_title：Cell death & disease

authors： Xu Y,Ge Z,Zhang E,Zuo Q,Huang S,Yang N,Wu D,Zhang Y,Chen Y,Xu H,Huang H,Jiang Z,Sun L

更新日期：2017-10-12 00:00:00

abstract：:Autophagy is a pivotal intracellular process by which cellular macromolecules are degraded upon various stimuli. A failure in the degradation of autophagic substrates such as impaired organelles and protein aggregates leads to their accumulations, which are characteristics of many neurodegenerative diseases. Pharmacol...

journal_title：Cell death & disease

authors： Yoon YS,Cho ED,Jung Ahn W,Won Lee K,Lee SJ,Lee HJ

更新日期：2017-10-05 00:00:00

abstract：:STAT1, which carries tumor suppressor functions in several models, consists of two isoforms, namely STAT1α and STAT1β. The biological function and significance of STAT1β has never been examined in human cancer. We examined STAT1β function in esophageal squamous cell carcinoma (ESCC) by transfecting a STAT1β gene into ...

journal_title：Cell death & disease

authors： Zhang Y,Chen Y,Yun H,Liu Z,Su M,Lai R

更新日期：2017-10-05 00:00:00

abstract：:Betulinic acid (BA) exhibits cytotoxic activity against some cancer cells. However, the molecular mechanism of BA against CRC cells was little reported. Here, we proved that BA elicited CRC cells' growth inhibition and apoptosis in a dose-dependent manner. In addition, BA treatment induced autophagy via inhibiting the...

journal_title：Cell death & disease

authors： Wang S,Wang K,Zhang C,Zhang W,Xu Q,Wang Y,Zhang Y,Li Y,Zhang Y,Zhu H,Song F,Lei Y,Bu Y

更新日期：2017-10-05 00:00:00

abstract：:Chemoresistance is one of the leading causes that contributes to tumor relapse and poor patient outcome after several rounds of drug therapy. The causes of chemoresistance are multi-factorial. Ultimately, it is the balance of pro- and anti-apoptotic activities in the cells. We have previously reported links between PO...

journal_title：Cell death & disease

authors： Weng T,Koh CG

更新日期：2017-09-14 00:00:00

abstract：:Effective management of breast cancer depends on early diagnosis and proper monitoring of patients' response to therapy. However, these goals are difficult to achieve because of the lack of sensitive and specific biomarkers for early detection and for disease monitoring. Accumulating evidence in the past several years...

journal_title：Cell death & disease

authors： Hamam R,Hamam D,Alsaleh KA,Kassem M,Zaher W,Alfayez M,Aldahmash A,Alajez NM

更新日期：2017-09-07 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most prevalent form of malignant brain tumor. Amlexanox, a novel compound, has been shown to have anti-cancer potential. In this study, the anti-tumoral effects and the underlying mechanisms of amlexanox were investigated. Amlexanox significantly suppressed proliferation and invasi...

journal_title：Cell death & disease

authors： Liu Y,Lu J,Zhang Z,Zhu L,Dong S,Guo G,Li R,Nan Y,Yu K,Zhong Y,Huang Q

更新日期：2017-08-31 00:00:00

abstract：:Bladder cancer (BCa) is the one of the most common cancers with high incidence, occurrence and low 5-year survival rate. Emerging evidence indicates that DLK1-DIO3 genomic region especially the miRNA cluster in this region is involved in several pathologic processes and various cancers, and miR-323a-3p is a member of ...

journal_title：Cell death & disease

authors： Li J,Xu X,Meng S,Liang Z,Wang X,Xu M,Wang S,Li S,Zhu Y,Xie B,Lin Y,Zheng X,Liu B,Xie L

更新日期：2017-08-24 00:00:00

abstract：:Current preclinical models in tumor biology are limited in their ability to recapitulate relevant (patho-) physiological processes, including autophagy. Three-dimensional (3D) growth cultures have frequently been proposed to overcome the lack of correlation between two-dimensional (2D) monolayer cell cultures and huma...

journal_title：Cell death & disease

authors： Bingel C,Koeneke E,Ridinger J,Bittmann A,Sill M,Peterziel H,Wrobel JK,Rettig I,Milde T,Fernekorn U,Weise F,Schober A,Witt O,Oehme I

更新日期：2017-08-24 00:00:00

abstract：:Erythropoietin (EPO) has been well known as a hematopoietic cytokine over the past decades. However, recent reports have demonstrated that EPO plays a neuroprotective role in the central nervous system, and EPO has been considered as a therapeutic target in neurodegenerative diseases such as ischemic stroke. Despite t...

journal_title：Cell death & disease

authors： Yoo SJ,Cho B,Lee D,Son G,Lee YB,Soo Han H,Kim E,Moon C,Moon C

更新日期：2017-08-17 00:00:00

abstract：:Hypertension-induced cardiac hypertrophy and attenuated cardiac function are the major characteristics of early stage heart failure. Cardiomyocyte death in pathological cardiac conditions is the primary cause of heart failure and mortality. Our previous studies found that heat shock factor 1 (HSF1) protected cardiomyo...

journal_title：Cell death & disease

authors： Huang CY,Pai PY,Kuo CH,Ho TJ,Lin JY,Lin DY,Tsai FJ,Padma VV,Kuo WW,Huang CY

更新日期：2017-08-10 00:00:00

abstract：:Cognitive aging is a leading public health concern with the increasing aging population, but there is still lack of specific interventions directed against it. Recent studies have shown that cognitive function is intimately affected by systemic milieu in aging brain, and improvement of systemic environment in aging br...

journal_title：Cell death & disease

authors： Cao N,Liao T,Liu J,Fan Z,Zeng Q,Zhou J,Pei H,Xi J,He L,Chen L,Nan X,Jia Y,Yue W,Pei X

更新日期：2017-08-10 00:00:00

abstract：:Inhibitors of apoptosis (IAP) proteins contribute to cell death resistance in malignancies and emerged as promising targets in cancer therapy. Currently, small molecules mimicking the IAP-antagonizing activity of endogenous second mitochondria-derived activator of caspases (SMAC) are evaluated in phase 1/2 clinical tr...

journal_title：Cell death & disease

authors： Bittner S,Knoll G,Ehrenschwender M

更新日期：2017-08-03 00:00:00

abstract：:Colorectal cancer (CRC) is the second major cause of tumor-related deaths. MicroRNAs (miRNAs) have pivotal roles in CRC progression. Here, we describe the effect of miR-181d on CRC cell metabolism and underlying molecular mechanism. Our data firmly demonstrated that knockdown of miR-181d suppressed CRC cell proliferat...

journal_title：Cell death & disease

authors： Guo X,Zhu Y,Hong X,Zhang M,Qiu X,Wang Z,Qi Z,Hong X

更新日期：2017-07-27 00:00:00

abstract：:Cellular senescence is an initial barrier to tumor development that prevents the proliferation of premalignant cells. However, some of the features of senescent cells seem to promote tumor progression via senescence-associated secretory phenotype (SASP). Here, we demonstrated that the protein level of forkhead box Q1 ...

journal_title：Cell death & disease

authors： Wang P,Lv C,Zhang T,Liu J,Yang J,Guan F,Hong T

更新日期：2017-07-20 00:00:00